LINKPHASE3: an improved pedigree-based phasing algorithm robust to genotyping and map errors
نویسندگان
چکیده
Many applications in genetics require haplotype reconstruction. We present a phasing program designed for large half-sibs families (as observed in plant and animals) that is robust to genotyping and map errors. We demonstrate that it is more efficient than previous versions and other programs, particularly in the presence of genotyping errors.
منابع مشابه
Effect of Genotype and Pedigree Error on Detection of Recombination Events, Sire Imputation and Haplotype Inference Using the Hsphase Algorithm
HSPhase is a fast and accurate algorithm for detection of recombination events, sire imputation and haplotype inference of half-sib families. It can be used on data for half-sib families with as few as 4 individuals in a family. The robustness of this algorithm in relation to genotype and pedigree errors was evaluated. If there were more than 20 half-sibs in a family, the performance of the alg...
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عنوان ژورنال:
- Bioinformatics
دوره 31 10 شماره
صفحات -
تاریخ انتشار 2015